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91.
92.
The detection of retinal microaneurysms is crucial for the early detection of important diseases such as diabetic retinopathy. However, the detection of these lesions in retinography, the most widely available retinal imaging modality, remains a very challenging task. This is mainly due to the tiny size and low contrast of the microaneurysms in the images. Consequently, the automated detection of microaneurysms usually relies on extensive ad-hoc processing. In this regard, although microaneurysms can be more easily detected using fluorescein angiography, this alternative imaging modality is invasive and not adequate for regular preventive screening.In this work, we propose a novel deep learning methodology that takes advantage of unlabeled multimodal image pairs for improving the detection of microaneurysms in retinography. In particular, we propose a novel adversarial multimodal pre-training consisting in the prediction of fluorescein angiography from retinography using generative adversarial networks. This pre-training allows learning about the retina and the microaneurysms without any manually annotated data. Additionally, we also propose to approach the microaneurysms detection as a heatmap regression, which allows an efficient detection and precise localization of multiple microaneurysms. To validate and analyze the proposed methodology, we perform an exhaustive experimentation on different public datasets. Additionally, we provide relevant comparisons against different state-of-the-art approaches. The results show a satisfactory performance of the proposal, achieving an Average Precision of 64.90%, 31.36%, and 33.55% in the E-Ophtha, ROC, and DDR public datasets. Overall, the proposed approach outperforms existing deep learning alternatives while providing a more straightforward detection method that can be effectively applied to raw unprocessed retinal images. 相似文献
93.
Researchers worldwide are taking advantage of novel, commercially available, technologies, such as ion mobility mass spectrometry (IM-MS), for metabolomics and lipidomics applications in a variety of fields including life, biomedical, and food sciences. IM-MS provides three main technical advantages over traditional LC-MS workflows. Firstly, in addition to mass, IM-MS allows collision cross-section values to be measured for metabolites and lipids, a physicochemical identifier related to the chemical shape of an analyte that increases the confidence of identification. Second, IM-MS increases peak capacity and the signal-to-noise, improving fingerprinting as well as quantification, and better defining the spatial localization of metabolites and lipids in biological and food samples. Third, IM-MS can be coupled with various fragmentation modes, adding new tools to improve structural characterization and molecular annotation. Here, we review the state-of-the-art in IM-MS technologies and approaches utilized to support metabolomics and lipidomics applications and we assess the challenges and opportunities in this growing field. 相似文献
94.
Yang Luo Shi-li Zheng Shu-hua Ma Chun-li Liu Xiao-hui Wang 《Journal of the European Ceramic Society》2018,38(16):5282-5293
A novel mullite-bonded SiC-whisker-reinforced SiC matrix composite (SiCw/SiC, SiC whisker-to-SiC powder mass ratio of 1:9) was designed and successfully prepared. Before preparing the composite, the inexpensive lab-made SiCw was first modified by an oxidation/leaching process and then coated with Al2O3. The kinetics results indicate that the oxidation process can be described by improved shrinking-cylinder models. The aspect ratio of SiCw improved after modification. Subsequently, raw materials with a SiC–SiO2–Al2O3 triple-layered structure were obtained after the Al2O3-coating process and used as feedstocks during the subsequent hot-pressing sintering. Finally, the characterization of the composites indicates that the mullite-bonded sample performs better (relative density of 93.8?±?1.4%, flexural strength of 533.3?±?18.2?MPa, fracture toughness of 13.6?±?2.1?MPa?m1/2, and Vickers hardness of 20.6?±?2.5?GPa) than the reference sample without the mullite interface. The improved toughness could essentially be attributed to the moderately strong interface bonding and effective load transfer effects of the mullite interface. 相似文献
95.
Baohua Zhang Dejian Dai Jichao Huang 《Critical reviews in food science and nutrition》2018,58(12):2099-2118
Over the past decades, imaging and spectroscopy techniques have been rapidly developing and widely applied in nondestructive fruit and vegetable quality assessment. The physical properties (including size, shape, color, position, and temperature) and biological properties (including cultivar, season, maturity level and geographical origin) of fruits and vegetables vary from one to another. A great variety of physical and biological properties of agricultural products influence the optical propagation properties and interaction behaviors with incident light, thus decreasing the quality inspection accuracy. Many attempts have been made in image correction and spectral compensation methods to improve the inspection accuracy. This paper gives a detailed summary about influence of physical and biological variability, as well as the correction and compensation methods for eliminating or reducing the effects in fruit and vegetable quality nondestructive inspection by using imaging and spectroscopy techniques. The advantages and disadvantages of the solution methods are discussed and summarized. Additionally, the future challenges and potential trends are also reported. 相似文献
96.
针对高强度采动巷道围岩控制难题,从实验室岩样尺度和现场巷道尺度研究了湾图沟煤矿13405工作面回风平巷围岩稳定性特征。结合单轴压缩试验和声波测试分析了干燥、自然及饱和状态下3组岩样的力学行为差异特征。利用钻孔成像,分析了高强度采动影响巷道围岩裂隙发育分段特征。结果表明:干燥、自然及饱和状态下岩样的单轴抗压强度和弹性模量依次降低,水分的存在极大地降低了岩石的强度和刚度。实煤体段围岩仅在深度1 m范围内发现少量纵向裂隙。高静压段两帮维护效果较差,煤帮裂隙极为发育,存在高量值的离层。动压段巷道顶板完整性较好,两帮均发现较大离层,且超出了锚杆正常锚固范围,严重影响了巷道锚固结构的稳定性。 相似文献
97.
George L. Burton Sandrine Ricote Brendan J. Foran David R. Diercks Brian P. Gorman 《Journal of the American Ceramic Society》2020,103(5):3217-3230
Dual phase oxide membranes have shown promising hydrogen permeation fluxes in syngas applications due to their high mixed proton electron conduction (MPEC). However, the conductivity of grain boundaries can be many orders of magnitude lower than that of the bulk and so limits the total conductivity and hydrogen permeation. In this study, the three-dimensional nanoscale oxygen and cation distributions around grain and phase boundaries in a BaCe0.8Y0.2O3-δ-Ce0.8Y0.2O2-δ (BCY-YDC) membrane were quantified by atom probe tomography (APT) and related to average grain boundary conductivity measured by electrochemical impedance spectroscopy (EIS). Segregation varied among the general high-angle grain boundaries analyzed, but no trend from orientation analysis was determined. Correlative APT and electron energy loss spectroscopy (EELS) of one YDC grain boundary revealed composition and cerium valence information, respectively, allowing for the determination of vacancies at the grain boundary. While a specific MPEC membrane is characterized, the results are relevant to proton and electron conduction in a number of technologically important ceramics. 相似文献
98.
基于UWB信号的井下探测成像系统中,根据Nyquist采样定理,提高发射信号的带宽以获取高分辨率,将导致大量的采样数据产生,过大的采样率将会在成像系统的硬件实现上带来很大困难。另一方面,在实际成像过程中,成像数据的完整性决定了最后成像结果的准确性,但由于存在不可避免的误差和噪声影响,以及塌方体阻碍下目标的隐蔽性,这些因素都将使得成像目标的回波数据无法满足成像要求。因此,在对目标回波进行成像处理之前,必须对回波数据进行处理,通过相关算法使回波数据满足理想的成像模型,最后聚焦方位向回波信息得到目标成像结果。为了提高穿透塌方体遮蔽目标成像的分辨率,并解决超宽带信号穿透塌方体成像得到方位向回波数据不足的问题,通过对传统的压缩感知成像算法进行分析介绍,结合井下具体成像环境,提出一种基于相位误差估计的CS成像算法对回波数据进行补偿。该算法的核心思想就是通过对回波数据计算得到相位误差,首先对回波信号的稀疏性进行验证,并构建目标信号的测量矩阵,利用CS成像算法对回波数据重构的同时对数据进行补偿,通过反复迭代误差估计,逐渐提高回波数据量和成像的质量。最后通过不同场景的仿真试验,验证所提算法在回波数据补偿问题上的有效性。 相似文献
99.
100.
Manas M. Mandalahalli Evert C. Wagner Luis M. Portela Robert F. Mudde 《American Institute of Chemical Engineers》2020,66(1):e16696
In this work, the effect of an electrolyte (up to 2 M of NaCl dissolved in water) on a homogeneous dense bubbly flow, in an airlift bubble column, is studied using nonintrusive techniques. X-ray and high-speed imaging are used to investigate the bubble size distribution, the local and the global gas-fraction profiles. The major effect of the electrolyte is the bubble size distribution at the fine-pore sparger, which is a consequence of the bubble coalescence inhibition promoted by the electrolyte. The bubble plume widening, the increase in overall gas fraction, and the onset of bubble recirculation in the column can all be explained by the bubble size reduction at the fine-pore spargers. As a result of the bubble size reduction, the overall role of the electrolyte is in a reduction of the driving force for the liquid recirculation. Furthermore, an accumulation of the small bubbles causes a layer of foam at the free surface, which is dynamic in nature and induces additional bubble recirculation. 相似文献